Haemodialysis Patients/Cytomegalovirus IgG Positive Infection in Babylon Governorate-Iraq

Abstract

Cytomegalovirus (CMV) is common throughout the world. This virus belongs to the 2-strand linear DNA genome and capsid, which is enclosed by an envelope, is a part of the 2-herpes virinae subfamily of the Herpesviridae family. Renal failure in dialysis patients is associated with numerous causes, such as UTIs or systemic diseases, so patients are at higher risk of developing a CMV infection. The men had a higher infection rate compared to women, and CMV infection rose as an individual grew older. Examining whether there is a correlation between CMV IgG positivity and haemodialysis patients was the primary goal of this research. February 2025 to December 2025 was the time frame of this investigation. The participants included 110 patients aged between 15-75 years old who were receiving hemodialysis due to chronic kidney disease. There were 68 males and 42 females. The findings of this study revealed that compared to the control group, patients with infected CMV, those on haemodialysis without infection and those on haemodialysis with infection all had an increased serum IL-1β levels (17.00±0.41, 26.17±0.51 and 35.00±1.68 pg/ml respectively) compared to the control group (8.04±0.23 pg/ml). At the same time, IL-6 levels were higher than the control level (23.09±0.48 pg/ml) (41.71±1.90, 66.00±2.28 and 115.00±3.50 respectively). Although TNF-α was lower than control (8.09±0.24 pg/ml) at 12.98±0.34, 21.00±0.41, and 37.09±0.46, respectively.