Estimate Correlation between Aspergillus Spp. and Asthma Patients

Fatima Basheer  Jeawel; Thalfa Abdul Wahab Abdul  Amir Tawoos; Reham Abdullah Ibrahim; Atyaf Muhammad  Nayef; Azhar Awdah Hassan; Diana Thamer Jaber; Saja jameel Hassan; Noor Ail Muhaisen

doi:10.52845/CMRO/2024/7-6-30

Fatima Basheer Jeawel ⁽¹⁾ , Thalfa Abdul Wahab Abdul Amir Tawoos ⁽²⁾ , Reham Abdullah Ibrahim ⁽³⁾ , Atyaf Muhammad Nayef ⁽⁴⁾ , Azhar Awdah Hassan ⁽⁵⁾ , Diana Thamer Jaber ⁽⁶⁾ , Saja jameel Hassan ⁽⁷⁾ , Noor Ail Muhaisen ⁽⁸⁾

(1) Thi Qar University, College of Science, Department of Chemistry , Iran, Islamic Republic of

(2) Thi Qar University/ college of science/Department of pathological analyses , Iran, Islamic Republic of

(3) Thi Qar University College of Science/Department of pathological analyses , Iran, Islamic Republic of

(4) Thi Qar University/ college of science/Department of pathological analyses , Iran, Islamic Republic of

(5) Thi Qar University/ college of science/Department of pathological analyses , Iran, Islamic Republic of

(6) Thi Qar University/ college of science/Department of pathological analyses , Iran, Islamic Republic of

(7) University of kufa / college of science / department of pathological analyses , Iran, Islamic Republic of

(8) Thi Qar University/ college of science/Department of pathological analyses , Iran, Islamic Republic of

https://doi.org/10.52845/CMRO/2024/7-6-30

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Vol. 7 No. 06 (2024)

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Abstract

Fungal exposure is a daily fact of human existence that infrequently results in disease; Asthma is a chronic inflammatory disease of the airways characterized by respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and in intensity. The relationship between day-to-day changes in asthma severity and combined exposures to community air pollutants and aeroallergens remains to be clearly defined. There is a close association between fungi and asthma, the so-called fungal asthma.

This study aimed to isolate the causative Aspergillus species that increase the risk of infection and to find out the association between asthma and Aspergillus spp. 40 sample of (sputum s and pharyngeal swabs) were collected from patients suffer from asthma symptoms. All samples were of both gender and of different age groups at the Specialized Center for Respiratory Diseases.

Samples were grown on two culture media (SDA and MEA) and incubated at 37°C for 7 days. The numbers of positive samples were 32 on SDA medium, 29 on MEA medium. Isolates were identified using special culture media characteristics as well as macroscopic and microscopic analysis. Where A. flavus was found to be the most predominant species of the sputum (58%) and from the pharyngeal swab (58.82%) on SDA, while on MEA the most prominent species were A. flavus and A. terreus (35%) of the sputum and the pharyngeal swab was A.niger (42.11%).

The Aspergillus genera showed resistance to Fluconazole, Amphotericin B and Nystatin.

The study has concluded that, there is a correlation between asthma and Aspergillus species. Aspergillus flavus the most common Aspergillus associated with lung diseases (Asthma).

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