Evaluation of Antibacterial and Antifungal Activity of Bioactive Chemical Compounds Isolated from Candida albicans

Abstract

Aims and Objective: The aims of this research were analysis of the bioactive chemical products of C. albicans and evaluation of antibacterial and in vitro antimicrobial activity of plant extracts on Candida albicans.

Method: Bioactives (chemical compounds often referred to as secondary metabolites) were analyzed using gas chromatography-mass spectroscopy (GC-MS) techniques, then the in vitro antibacterial and antifungal activity of the Candida albicans methanolic extract was evaluated.

Results: GC-MS analysis of Candida albicans revealed the existence of the: methyl ester-2-methyl-7,9-methyl-bor ,dicarbonyl-(n-4-pinocarvone)[1,2-bis(dimethylphosphi,  Lycoxanthin , 12-Butanol , 3-chloro-,(R*,R*)- , 8,11-Octadecadiynoic acid , methyl ester , 6-Acetyl-β-d-mannose , Thieno[2,3-c]furan-3-carbonitrile,2-amino-4,6-dihydro-4,4,6,6-tetra , 17-Octadecynoic acid , N,N'-bis(2-hydroxyethyl)- , 5-Methyl-6-phenyltetrahydro-1,3-oxazine-2-thione , 1-Propyl-3,6-diazahomoadamantan-9-ol , Stearic acid , α-D-Glucopyranoside, O-α-D-glucopyranosyl-(1.fwdarw.3)-β- , Lactose ,  Cyclopropanebutanoic acid , Estra-1,3,5(10)-trien-17β-ol , Benzenemethanol,4-[(ethylpropyl)amino]-2-methyl-3,5-dinitro-  and [1,1'-Bicyclopropyl]-2-octanoic acid , 2'-hexyl-,methyl ester, D-Glucose , 6-O-α-D-galactopyranosyl- , α-D-Glucopyranoside , O-α-D-glucopyranosyl-(1.fwdarw.3)-β- , 6-Acetyl –β-d-mannose , 9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol,(3β,5Z,7E)- and  Pyrimidin-2-ol,4-(3,4-dimethoxyphenyl)-6-phenyl, Orcinol, Bicyclo[2.2.1]heptane-2-carboxylic acid isobutyl-amide, 2H-Oxecin-2-one.3.4.7.8.9.10-hexahydro-4-hydroxy-10-methyl-.[4, 2H-Pyran,tetrahydro-2-(12-pentadecynyloxy), Maltol, 2-Tridecyl-5-(acetylamino)tetrahydro-γ-pyrone, Cycloundecanone , oxime, D-Glucose,6-O-α-D-galactopyranosyl, 6-Acetyl-ß-d-mannose, 5-Hydroxymethylfurfural, 1-Gala-l-ido-octonic lactone. Candida albicans metabolites was very highly active against Staphylococcus epidermidis (5.97±0.04).