PHYSIOLOGICAL ROLE OF HUNTERIA UMBELLATA FRUIT EXTRACT ON HORMONAL AND RENAL PROFILE IN CADMIUM INDUCED TOXICITY MALE WISTAR RATS

Abstract

The present study was design with an objective to investigate the toxicity level of cadmium chloride on hormonal and biochemical markers and the restoration strength of Hunteria umbellata aqueous fruit extract administered at various dosage level of treatment in induced male wistar rats. The parameters investigated includes LH,FSH, Testosterone, Prolactin, Urea, Creatinine, and Uric acid following 0.07ml and 0.06ml single dose cdcl₂ induction of group2 and group3.However group4 was administered 0.03ml cdcl₂ daily while group1 serve as the control.Group2 was treated at 400mg/kg and group3 at 200mg/kg extract daily while group4 received no treatment but feed  and water ad libidum.Results from this study shows higher FSH (0.52 m/u/ml), LH (1.32 m/u/ml) and Prolactin (1.17ng/ml) among group3 treated at 200mg/kg extract of the Hunteria umbellata fruit. This was closely followed by group2 treated at 400mg/kg body weight ie LH (0.74 m/u/ml), Prolactin (1.04ng/ml) compared with group4 FSH of (0.25 m/u/ml), LH (0.37 m/u/ml) and control. The testosterone level was higher in group2 (4.65 ng/ml) compared with other groups. The study shows higher renal markers in group4 administered cdcl₂ without treatment. However in group2 treated at 400mg/kg extract had decreased renal markers followed by group3 treated at 200mg/kg extract.ie results from this study further indicate higher renal indices among group4 administered oral cdcl₂ daily with urea having (10.70mmol/l), Creatinine (178.5µmol/l) and uric acid (430.0µmol/l) compared with the control group of (9.6mmol/l),(165µmol/l) and (375µmol/l) respectively.

This study have shown clearly the physio-pharmacological effect of Hunteria umbellata fruit extract in increasing glomerullar filtration rate to clear off these parameters from the blood and restore normal renal function.