Regulatory Innate Lymphoid Cells: A New Subset of Innate Immune Lymphocytes with More Potential Functions to be Discovered in Immune Regulation.

Jifeng Yu; Yingmei  Li; Weijie  Cao; Zhongxing  Jiang; Zhongxing  Jiang; Dingming  Wan

doi:10.15520/jcmro.v3i01.251

Jifeng Yu ⁽¹⁾ , Yingmei Li ⁽²⁾ , Weijie Cao ⁽³⁾ , Zhongxing Jiang ⁽⁴⁾ , Zhongxing Jiang ⁽⁵⁾ , Dingming Wan ⁽⁶⁾

(1) Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 450052 , China

(2) Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 450052 , China

(3) Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 450052 , China

(4) Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 450052 , China

(5) Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 450052 , China

(6) Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 450052 , China

https://doi.org/10.15520/jcmro.v3i01.251

Issue
Vol. 3 No. 01 (2020)

Keywords:

Regulatory innate lymphoid cell, ILCregs; Immune regulation

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Abstract

Regulatory innate lymphoid cells (ILCregs) are a newly identified subset of innate immune lymphocytes. The discovery of this subset cell has revealed several inhibitory and stimulatory pathways that affect the regulatory functions of ILCregs, in addition to miRNA and other genetic molecular regulations. These pathways may play important roles in the pathogenesis and potential immunotherapy in patients with different kind of diseases, such as inflammation and ischemia / reperfusion injury of the kidney, acute myeloid leukemia, through immunomodulatory and anti-inflammatory pathway, as well as miRNA regulations. Further studies on ILCregs may be a potentially high interest in the near future.