Olfactory Neuroblastoma Presenting as Fibro-Osseous Lesion of Maxillary Bone

Abstract

A seven year female child reported to department of oral and maxillofacial surgery with complaint of swelling at left upper jaw since 5months. Provisional diagnosis of fibro-osseus lesion was made and curettage was done. After 2 months, patient again appeared with complain of swelling of left maxilla and neck. Computed tomography (CT) scan of face and neck was done which was suggestive of osteodestructive, osteoexpansile mildly homogenously enhancing soft tissue lesion involving left maxilla with features and extension as described-neoplastic etiology. (? Rhabdomyosarcoma ?? lymphomatous infiltration) while histomorphology and immunohistochemistry report revealed olfactory neuroblastoma (ONB)with positivity of synaptophysin, CD-56 and FLI-1. Ki prolification index was 60-70%. Patient was given chemotherapy but did not respond.