In Vitro Antibacterial Activity of Cinnamomum zeylanicum and Screening of Its Bioactive Compounds

Al-Zubaidi Sura (1)
(1) Medical Biotechnology Department, College of Biotechnology, Al-Qasim Green University, Babylon, 51013, Iraq , Iraq

Abstract

Background: Cinnamomum zeylanicum is a plant containing antimicrobial properties in the extracts. It is the presence of compounds like cinnamaldehyde that makes it possess an antibacterial effect and it does act as such to bacteria.


Materials and Methods: Cinnamon sticks of Cinnamomum zeylanicum were dried and ground in a mortar and pestle at room temperature level. Three cold extractions (25 0 C) and 72 hours were carried out to macerate the plant samples in order to obtain ethanol extracts of 80% (v/v) concentration. Extraction of volatile bioactive chemicals through GC-MS. GC is then employed to determine the component constituents of the essential oils and the molecular mass of those constituents is determined by subsidizing Mass Spectrometry (MS) using fragmentation.


Results: The components of findings were fifteen in the case of C. zeylanicum following a GC-MS analysis. These are; 9,12-octadecadienoic acid (Z,Z)-, Cinnamic alcohol, PALmitic acid vinyl ester, Caryophyllene, Trans -2-decenal, Eugenol, D-limonene, Hexadecanoic acid, ethyl ester, 6-Methyl-5-hepten-2-one, Benzaldehyde, Cinnamic aldehyde, Phenyl ethyl acetate and 6-Methyl-5-hepten Enterococcus faecalis (26.09±0.43) was demonstrated to have a strong efficacy on the metabolites of Cinnamomum zeylanicum.

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References

Ranjbar A, Ghasmeinezhad S, Zamani H, Malekirad AA, Baiaty A, Mohammadirad A, et al. Antioxidative stress potential of Cinnamomum zeylanicum in humans: a comparative cross-sectional clinical study. Therapy.2021;3(1):113-7.

Ghosh T, Basu A, Adhikari D, Roy D, Pal AK. Antioxidant activity and structural features of Cinnamomum zeylanicum. 3 Biotech. 2015;5(6):939-47.

El-Baroty GS, Abd El-Baky HH, Farag RS, Saleh MA. Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. African J Biochem Res.2010;4(6):167-74.

Dudonné S, Vitrac X, Coutiére P, Woillez M, Mérillon JM. Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. J Agric Food Chem.2009;57(5):1768-74.

Rao PV, Gan SH. Cinnamon: A multifaceted medicinal plant. Evidencebased Complement Altern Med. 2014; 2014:1-13.

Azad R, Kumara KLW, Senanayake G, Ranawaka RAAK, Pushpakumara DKNG, Geekiyanage S. Flower morphological diversity of cinnamon (Cinnamomum verum Presl) in Matara District, Sri Lanka. Open Agric.2018;3(1):236-44.

Sharma G, Nautiyal AR. Cinnamomum tamala: A valuable tree of Himalayas. J Med Aromat Plants.2011;1(1):1-4.

Kitazuru ER, Moreira AVB, Mancini-Filho J, Delincée H, Villavicencio ALCH. Effects of irradiation on natural antioxidants of cinnamon (Cinnamomum zeylanicum N.). Radiat Phys Chem. 2004;71(1-2):39-41.

Nimse SB, Pal D. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv. 2015;5(35):27986- 8006.

Arisha SM, Sakr SA, Abd-Elhaseeb FR. Cinnamomum zeylanicum alleviate testicular damage induced by high fat diet in albino rats; histological and ultrastructural studies. Heliyon. 2020;6(11):1-14.

Castro JC, Pante GC, Centenaro BM, Almeida RTR De, Pilau EJ, Dias Filho BP, et al. Antifungal and antimycotoxigenic effects of Zingiber officinale, Cinnamomum zeylanicum and Cymbopogon martinii essential oils against Fusarium verticillioides. Food Addit Contam Part A.2020;37(9):1531-41.

Adarsh A, Chettiyar B, Kanthesh B, Raghu N. Phytochemical Screening and Antimicrobial Activity of “Cinnamon zeylanicum.” Int J Pharm Res Innov. 2020;13:22-33.

Jayaprakasha GK, Rao LJM. Chemistry, Biogenesis, and Biological Activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr.2011;51(6):547-62.

Kubatka P, Kello M, Kajo K, Samec M, Jasek K, Vybohova D. Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses. Molecules. 2020;25(6):1-32.

Abdeen A, Abdelkader A, Abdo M, Wareth G, Aboubakr M, Aleya L. Protective effect of cinnamon against acetaminophen-mediated cellular damage and apoptosis in renal tissue. 2019;26:240-9.

Peterson DW, George RC, Scaramozzino F, Lapointe NE, Anderson RA, Graves DJ. Cinnamon extract inhibits tau aggregation associated with alzheimer’s disease in vitro. J Alzheimer’s Dis. 2009 Jan 1;17(3):585-97.

Alqasoumi S. Anti-secretagogue and antiulcer effects of “cinnamon” Cinnamomum zeylanicum in rats. J Pharmacogn Phyther.2012;4(4):53-61.

Tang PL, Chen YT, Qin J, Hou X, Deng J. Effect of cinnamon bark and twig extracts on the chemical, physicochemical and antioxidant properties of fermented milk. J Food Meas Charact.2020;14(4):2271-81.

Fabbri J, Maggiore MA, Pensel PE, Denegri GM, Elissondo MC. In vitro efficacy study of Cinnamomum zeylanicum essential oil and cinnamaldehyde against the larval stage of Echinococcus granulosus. Exp Parasitol. 2020;214:107904.

Beji RS, Khemir S, Wannes WA, Ayari K, Ksouri R. Antidiabetic, antihyperlipidemic and antioxidant influences of the spice cinnamon (Cinnamomum zeylanicumon) in experimental rats. Brazilian J Pharm Sci;54(2):17576.

Dorri M, Hashemitabar S, Hosseinzadeh H. Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol. 2018;41(3):338-51.

Authors

Al-Zubaidi Sura
Sura, A.-Z. (2025). In Vitro Antibacterial Activity of Cinnamomum zeylanicum and Screening of Its Bioactive Compounds. Journal of Current Medical Research and Opinion, 8(10), 4477–4485. https://doi.org/10.52845/CMRO/2025/8-10-4

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