Age and Gender Distribution of Enteric Adenovirus and Rotavirus Infections among Pediatric Population and Determination the Level of IL-6, IL-8 and IL-10
Abstract
The onset of acute gastroenteritis due to viral infection mostly occurs during early childhood. Two viruses namely rotavirus and enteric adenovirus serve as the leading agents which trigger acute gastroenteritis in children and infants. The objective of this retrospective study involved evaluating demographic information alongside the frequency of rotavirus and enteric adenovirus antigen testing in hospitalized pediatric patients at our medical facility. Medical reviewers examined all hospital patients between October 2023 and March 2024 who presented with diarrhoea symptoms until their stool samples received testing. Stool antigen testing for rotavirus and enteric adenovirus occurred through the use of an immunochromatographic assay. The rotavirus stands as the leading factor in child acute gastroenteritis according to Babylon Hospital for Women and Children. A proper diagnosis of gastroenteritis depends on frequent testing for rotavirus and adenovirus antigens in recent stool samples. Viruses lead to most cases of gastroenteritis among children during their childhood. The Babylon Governorate area of our hospital underwent analysis revealing that rotavirus and adenovirus act as the two primary microorganisms causing gastroenteritis infections particularly prevalent among children in their 5-24 months period during autumn-winter months. Knowledge about the gastroenteritis origin in young children under two years old would promote swift patient recovery and reduce unnecessary healthcare expenses. The study of these conditions serves as a crucial requirement to spread understanding about the condition among impoverished populations who reside in Babylon Governorate. The scientists determined the lymphoblast fraction compared to complete lymphocytes based on transformation rates between study groups and controls (62.91 ± 11.45).
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References
Rheingans RD, Heylen J, Giaquinto C. Economics of rotavirus gastroenteritis and vaccination in Europe: what makes sense?. Pediatr Infect Dis J. 2006;25(1 Suppl):S48–55.
Davidson GP, Bishop RF, Townley RR, Holmes IH. Importance of a new virus in acute sporadic enteritis in children. Lancet. 1975;1(7901):242–
Carlson JA, Middleton PJ, Szymanski MT, Huber J, Petric M. Fatal rotavirus gastroenteritis: an analysis of 21 cases. Am J Dis Child. 1978;132(5):477–9.
Midthun K, Greenberg HB, Hoshino Y, Kapikian AZ, Wyatt RG, Chanock RM. Reassortant rotaviruses as potential live rotavirus vaccine candi- dates. J Virol. 1985;53(3):949–54. [PubMed: 2983101].
World Health O. Rotavirus vaccines. Wkly Epidemiol Rec. 2007;82(32):285–95.
Akinci N. , Ercan T. E. , Yalman N. , Eren A. , Severge B. , Ercan G. . The Frequency of Rotavirus in Children with Acute Gastroenteritis. J Clin Anal Med. 2015;6(4):449–51.
doi: 10.4328/jcam.2156.
Altindis M, Bastepe G, Ceri A, Yavru S, Kalayci R. Frequency of rotavirus and enteric adenovirus infection in children with acute gastroenteritis. SDU J Faculity Med. 2008;15(2):17–20.
Ilktac M, Sahin A, Nazik H, Ongen B. Investigation of Rotavirus Frequency and Following up the Rotavirus Season among Children with Acute Gastroenteritis: Evaluation of Five-year Results. J ANKEM. 2012;26(1):25–9.
doi: 10.5222/ankem.2012.025.
Simsek Y, Bostanci I, Bozdayi G, Oner N, Kamruddin A. S. Route 0-5 age rotavirus serotype prevalence and characteristics of acute gastroenteritis in children. Turkiye Klin J Pediatr. 2007;16(3):165–70.
Nazik H, Ilktac M, Ongen B. Evaluation of incidence of rotavirus gastroenteritis in pediatric age group. J ANKEM. 2006;20(4):233–5.
Bicer S, Sahin GT, Koncay B, Yavuzcan D, Gemic IH, Engerek N. , et al. Frequency of gastroenteritis in pediatric emergency department. J Pediatr Inf. 2008;3(2):96–9.
Palanduz A. Infectious gastroenteritis: etiologic agents and clinical assessment. J Pediatr Inf. 2009;3(2):116–8.
Bicer S, Bezen D, Sezer S. Rotavirus and adenovirus infections in acute gastroenteritis cases in pediatric emergency service. J ANKEM. 2006;20(4):206–9.
Kurugol Z, Geylani S, Karaca Y, Umay F, Erensoy S, Vardar F, et al. Rotavirus gastroenteritis among children under five years of age in Izmir, Turkey. Turk J Pediatr. 2003;45(4):290–4. [PubMed: 14768791].
Tekin A. The frequency of rotavirus and enteric adenovirus in children with acute gastroenteritis in Mardin. J Clin Exp Invest. 2010;1(1):41–5.
Bayraktar B, Toksoy B, Bulut E. Investigation of rotavirus and adenovirus in children with acute gastroenteritis. J KLIMIK. 2010;23(1):15–7.
Coban B, Topal B. Evaluation of rotavirus gastroenteritis in children: five years’ surveillance in Alanya, Antalya. Turk J Pediatr. 2014;56(3):280–4. [PubMed: 25341600].
Dagi HT, Findik D. . Investigation of rotavirus and adenovirus antigens in patients with acute gastroenteritis. J Clin Exp Invest. 2014;5(2):256–60.
Bates PR, Bailey AS, Wood DJ, Morris DJ, Couriel JM. Comparative epidemiology of rotavirus, subgenus F (types 40 and 41) adenovirus and astrovirus gastroenteritis in children. J Med Virol. 1993;39(3):224–8.
Heaton PM, Goveia MG, Miller JM, Offit P, Clark HF. Development of a pentavalent rotavirus vaccine against prevalent serotypes of rotavirus gastroenteritis. J Infect Dis. 2005;192 Suppl 1:S17–21.
Yousefi Rad A, GoZalan A. Detection of Rotavirus and Enteric Adenovirus Antigens in Outpatients with Gastroenteritis. Turkey Clin J Med Sci. 2010;30(1):174–9. doi: 10.5336/medsci.2008-9735.
Uhnoo I, Wadell G, Svensson L, Johansson M. Two new serotypes of enteric adenovirus causing infantile diarrhoea. Dev Biol Stand. 1983;53:311–8.
Hoshino T, Hosokawa N, Yanai M, Kumasaka K, Kawano K. A study of serum mitochondrial enzymes(mCK, mAST, mMDH) in rotavirus and adenovirus gastroenteritis in pediatric patients. Rinsho Byori. 2001; 49(11):1157–61.
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