Development of a simultaneous screening method for pregabalin, tramadol, O-desmethyl-tramadol, trihexyphenidyl, oxazepam, midazolam, clonazepam, zolpidem, and buprenorphine in urine using GC-MS
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GC-MS, Urine, Prégabaline, Tramadol, O-Desmethyl-Tramadol, Trihexyphénidyl, Oxazépam, Midazolam, Clonazépam, Zolpidem, Buprénorphine.
Abstract
Confirmation of positive results of immunological urine screening tests for psychotropic drugs is a key element in the fight against drug abuse, drug dependence, and misuse. Our work aims to develop a chromatographic technique for urine analysis by GC-MS for the simultaneous detection and identification of all psychotropic drugs defined by Algerian legislation. The retention times of pregabalin, tramadol, ODMT, trihexyphenidyl, oxazepam, midazolam, clonazepam, zolpidem, and buprenorphine were 12.76, 19.36, 20, 22.81, 23.4, 25.57, 26, 27.22, and 32.19 minutes, respectively. The detection limits estimated by graphical approach were acceptable for confirmation of the CUT-OFF of immunological screening techniques. The present technique offers sufficient sensitivity and efficiency for confirmation of positive results of immunological methods for screening psychotropic drugs in patient urine samples.
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