Bioactive Natural Compounds of Zingiber officinale Using Gas Chromatography-Mass Spectrometry and Evaluation of Its Antibacterial Activity

Rabab J.H. Al Hasseny (1) , Abbas K. Al-Mansoori (2) , Ahmed Obaid Hossain (3)
(1) Medical Microbiology, Department of Health Food and Nutrition, College of Food Science, Al-Qasim Green University, Iraq. , Barbados
(2) Department of Genetic Engineering, College of Biotechnology, Al-Qasim Green University, Iraq. , Iraq
(3) Department of Medical Biotechnology, College of Biotechnology, Al-Qasim Green University, Iraq. , Iraq
https://doi.org/10.52845/CMRO/2023/6-11-9

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Vol. 6 No. 11 (2023)
Keywords:
    Zingiber officinale, Phytochemicals, GC-MS, Antibacterial Activity
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Abstract

Chemical molecules that are found in plants and are sometimes referred to as secondary metabolites are called phytochemicals. The methanolic extract of Zingiber officinale was analyzed, and it was found to contain bioactive phytochemical components. The peak area, molecular weight, molecular formula and retention time, are the three criteria that are used to determine the identity of phytochemical substances. Analysis of Zingiber officinale using gas chromatography-mass spectrometry (GC-MS) uncovered the presence of the Longfolene, 2-(4-Nitrobutyryl)-cyclooctanone, 1, 1-Diphenyl- 4-phenyl - thiobut-3-en-1-ol, Cholestan-3 -ol, 2-methylene-,(3ß,5), ß-Bisabolene, and l-(+)-Ascorbic acid are some of the compounds that were found in the mixture. 2,6-dihexadecanoate, 9,12- Octa-decadienoic acid (Z,Z)-, methyl ester, 1-Heptatriacotanol, 10,13-Eicosadienoic acid, methyl ester, E,E,Z-1, 3,12-Nonadecatriene-5,14-diol, 9-Octadecenamide,(Z), and decyl oct- 3- yl ester are the components that make up this compound. The evaluation of antibacterial activity indicated that metabolites of Zingiber officinale were extremely potent against Proteus mirabilis (19.13±0.07).

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Authors

Rabab J.H. Al Hasseny
Medical Microbiology, Department of Health Food and Nutrition, College of Food Science, Al-Qasim Green University, Iraq.
Abbas K. Al-Mansoori
Department of Genetic Engineering, College of Biotechnology, Al-Qasim Green University, Iraq.
Ahmed Obaid Hossain
Department of Medical Biotechnology, College of Biotechnology, Al-Qasim Green University, Iraq.
Hasseny , R. J. A. ., Al-Mansoori , A. K. ., & Hossain , A. O. . (2023). Bioactive Natural Compounds of Zingiber officinale Using Gas Chromatography-Mass Spectrometry and Evaluation of Its Antibacterial Activity. Journal of Current Medical Research and Opinion, 6(11), 1876–1883. https://doi.org/10.52845/CMRO/2023/6-11-9
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