The Association of Antiphospholipid Syndrome Stimulated by Cytomegalovirus Infection with Pregnancy Outcome Among Women with Bad Obstetric History in Babil/ Iraq
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Antiphospholipid, APL, CMV, Cytomegalovirus, pregnant, ELIZA, Iraq
Abstract
Earlier studies have shown a significant correlation between Cytomegalovirus (CMV) infectivity and adverse pregnancy outcome, worldwide. A correlation also has been shown for Antiphospholipid (APL) syndrome and pregnancy outcome in developing countries like Iraq. However, there is a paucity of data informing the association of both APL and CMV infections in pregnancy outcome from that part of the globe.
This descriptive case control study was undertaken in Babil/ Iraq to determine the local seroprevalence of APL in women of child bearing age with and without CMV infection, to identify the socio-demographic factors associated with them, and to investigate whether or not it is important to screen post CMV women with Bad Obstetric History (BOH) for APL antibodies. This study found an overall seropositivity of 25.7% for APL IgG among patient group. The seroprevalence of past and current infections of APL levels was highest amongst those who were educated for < 6 years (25.8, 75)% and overcrowded (22.9, 75)%, respectively. A significant correlation (P=0.04) was found between APL IgG and abortion. A significant correlation (P= 0.02) was also noted for concurrent infection with both CMV+ve & APL+ve and abortion. The seroprevalence of APL IgG among age group was highest (31%) among patient aged 21-29 Yrs old, whereas for APL IgM, the peak (50%) was at age >30-39. This study concludes that APL screening of women post CMV infection might be of high importance especially for women with BOH. This will effectively aid to implement the adequate intervention methods that improve pregnancy outcomes.
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