Relationship Between Anxiety and Depression Levels and Suicide in Restless Legs Syndrome

Adnan Burak BİLGİÇ (1) , İlker ÖZDEMİR (2)
(1) University of Health Sciences Haydarpasa Numune Education And Research Hospital Department of Neurology , Turkey
(2) Giresun University, Faculty of Medicine, Department of Psychiatry , Turkey

Abstract

Background:Restless legs syndrome (RLS) is a common neurological disease. RLS can cause serious problems especially in transition to sleep and in the continuation of sleep. Since RLS is a treatable neurological disease, it is important to diagnose it. Since there is a close relationship between depression and RLS, suicide or suicide attempt may be a cause of high mortality in depression due to RLS. we wanted to emphasize.


Materials and Methods: A total of 171 individuals, 82 individuals diagnosed with RLS and 89 healthy individuals without RLS diagnosis, were included by random sampling method. After the necessary information was given to those who volunteered to participate in the study and their consent was obtained, the necessary evaluation scales were applied through face-to-face evaluation interviews.


Results:When the participants were compared according to their age; The age of the patient group ranged from 20 to 75 and the mean age was 52.52±14.64. When the groups were compared according to the scale scores; BAI and RLSSS scores of the patient group were significantly higher than the control group. When the scale scores were compared according to the RLS stages; There was a significant difference between the BDI scores according to the stages. Considering the correlations of scale scores in the patient group; No significant correlation was observed between RLSSS and BID scores.


 


Conclusions: Somatoform disorder and chronic pain were found to be high in RLS. Depression and anxiety disorders can be seen more frequently in RLS patients, especially due to sleep disturbance caused by RLS. Although suicidal thoughts were reported to be higher in people with RLS, our study indicated that the suicide rate did not increase in individuals with RLS.


 


Key words: Restless legs syndrome, Depression and anxiety disorder, Suicide

Full text article

Generated from XML file

References

1. Berger K, Kurth T. RLS epidemiology--frequencies, risk factors and methods in population studies. Mov Disord 2007;22:420-423. https://doi.org/10.1002/mds.21589
2. Allen RP, Walters AS, Montplaisir J, et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 2005;165:1286-1292. https://doi.org/10.1001/archinte.165.11.1286
3. Walters AS. Toward a better definition of the restless legs syndrome. The international restless legs syndrome study group. Mov Disord 1995;10:634-642. https://doi.org/10.1002/mds.870100517
4. Trenkwalder C, Hening WA, Walter AS, Campbell SS, Rahman K, Chokroverty S. Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome. Mov Disord 1999;14:102-110.
https://doi.org/10.1002/1531-8257(199901)14:1<102::aid-mds1017>3.0.co;2-e
5. Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function in rest-less legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology 1999;52:932-937.
https://doi.org/10.1212/wnl.52.5.932
6. Ruottinen HM, Partinen M, Hublin C, et al. An FDOPA PET study in pa-tients with periodic limb movement disorder and restless legs syndrome. Neurology 2000;54:502-504.
https://doi.org/10.1212/wnl.54.2.502
7. Wetter TC, Collado Seidel V, Pollmacher T, Yassouridis A, Trenkwal-der C. Sleep and periodic movement patterns in drug-free patients with Par-kinson’s disease and multiple bsystem atrophy. Sleep 2000;23:361-367.
8. Goodman JD, Brodie C, Ayida GA. Restless legs syndrome in preg-nancy. BMJ 1988;297:1101-1102.
https://doi.org/10.1136/bmj.297.6656.1101-a
9. Rothdach AJ, Trenkwalder C, Haberstock J, Keil U, Berger K. Preva-lence and risk factors of RLS in an elderly population: the MEMO study. Memory and morbidity in augsburg elderly. Neurology 2000;54:1064-1068. https://doi.org/10.1212/wnl.54.5.1064
10. Winkelmann J, Prager M, Lieb R, et al. “Anxietas tibiarum”. Depression and anx-iety disorders in patients with restless legs syndrome. J Neurol 2005;252:67-71.
https://doi.org/10.1007/s00415-005-0604-7
11. Lee HB, Hening WA, Allen RP, et al. Restless legs syndrome is associated with DSM-IV major depressive disorder and panic disorder in the community. J Neu-ropsychiatry Clin Neurosci 2008;20:101-105. https://doi.org/10.1176/jnp.2008.20.1.101
12. Cho SJ, Hong JP, Hahm BJ, et al. Restless legs syndrome in a community sam-ple of Korean adults: prevalence, impact on quality of life, and association with DSM-IV psychiatric disorders. Sleep 2009;32:1069-1076.
13. Kushida CA, Allen RP, Atkinson MJ. Modeling the causal relationships between symptoms associated with restless legs syndrome and the patient-reported im-pact of RLS. Sleep Med 2004;5:485-488.
https://doi.org/10.1016/j.sleep.2004.04.004
14. Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the sleep heart health study. Sleep 2009;32:772-778. https://doi.org/10.1093/sleep/32.6.772
15. Turecki G, Brent DA. Suicide and suicidal behaviour. Lancet 2016;387:1227-1239. https://doi.org/10.1016/S0140- 6736(15)00234-2
16. Winkelmann J, Prager M, Lieb R, et al. “Anxietas tibiarum”. Depression and anx-iety disorders in patients with restless legs syndrome. J Neurol 2005;252:67-71. https://doi.org/10.1007/s00415-005-0604-7
17. Para KS, Chow CA, Nalamada K, et al. Suicidal thought and behavior in indi-viduals with restless legs syndrome. Sleep Med 2019;54:1-7. https://doi.org/10.1016/j.sleep.2018.09.019
18. Talih F, Ajaltouni J, Kobeissy F. Restless leg syndrome in hospitalized psychiat-ric patients in Lebanon: a pilot study. Neuropsychiatr Dis Treat 2016;12:2581-2586. https://doi.org/10.2147/NDT.S116271
19. Holly H, Sally C, Curtin MA, Warner M. Suicide mortalityin the United States, 1997-2017: NCHS data brief No. 330, November 2018
20. Godau J, Spinnler N, Wevers AK, Trenkwalder C, Berg D. Poor effect of guide-line based treatment of restless legs syndrome in clinical practice. J Neurol Neurosurg Psychiatry 2010;81:1390-1395.
https://doi.org/10.1136/jnnp.2010.211417
21. Evans AH, Strafella AP, Weintraub D, Stacy M. Impulsive and compulsive be-haviors in Parkinson’s disease. Mov Disord 2009;24:1561-1570. https://doi.org/10.1002/mds.22505
22. Cornelius JR, Tippmann Peikert M, Slocumb NL, Frerichs CF, Silber MH. Im-pulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study. Sleep 2010;33:81-87.
23. Salas RE, Allen RP, Earley CJ, Gamaldo CE. Drug hoarding: a case of atypical dopamine dysregulation syndrome in a RLS patient. Movement Disorders 2009;24:627-628. https://doi.org/10.1002/mds.22443
24. Hornyak M. Depressive disorders in restless legs syndrome: epidemiology, pathophysiology and management. CNS Drugs 2010;24:89-98. https://doi.org/10.2165/11317500-000000000-00000
25. Gorman CA, Dyck PJ, Pearson JS. Symptoms of restless legs. Arch Intern Med 1965;115:155-160.
https://doi.org/10.1001/archinte.1965.03860140035008
26. Sevim S, Dogu O, Kaleagasi H, Metin O, Camdeviren H. Correlation of anxiety and depression symptoms in patients with restless legs syndrome: a population based survey. J Neurol Neurosurg Psychiatry 2004;75:226-230.
27. Zhuang S, Na M, Winkelman JW, et al. Association of restless legs syndrome with risk of suicide and self-harm. JAMA Network Open 2019;2:e199966. https://doi.org/10.1001/jamanetworkopen.2019.9966
28. Para KS, Chow CA, Nalamada K, et al. Suicidal thought and behavior in indi-viduals with restless legs syndrome. Sleep Med 2019;54:1-7. https://doi.org/10.1016/j.sleep.2018.09.019
29. Pigeon WR, Pinquart M, Conner K. Meta-analysis of sleep disturbance and sui-cidal thoughts and behaviors. J Clin Psychiatry 2012;73:1160-1167. https://doi.org/10.4088/JCP.11r07586

Authors

Adnan Burak BİLGİÇ
bilgicadnan0@gmail.com (Primary Contact)
İlker ÖZDEMİR
BİLGİÇ, A. B., & ÖZDEMİR, İlker. (2022). Relationship Between Anxiety and Depression Levels and Suicide in Restless Legs Syndrome. Journal of Current Medical Research and Opinion, 5(01). https://doi.org/10.52845/CMRO/2022/5-1-2
Copyright and license info is not available

Article Details