Assessment of Corneal Endothelial Changes in Patients of Pseudo Exfoliation Using Non-contact Specular Microscopy
Abstract
Background:
An altered composition and increased flare intensity of the aqueous humor caused by a breakdown of the blood aqueous barrier in eyes having PEX syndrome which cause corneal endothelial changes.
Aims:
To evaluate changes in the corneal endothelial morphology in patients with pseudo exfoliation (PEX) syndrome.
Setting and Design:
Tertiary care center of ophthalmology, Ahmedabad, India.
Materials and Methods:
Study included 220 eyes in a tertiary referral care center. In this group of patients there were 110 eyes with PEX syndrome and 110 eyes normal without PEX syndrome. Endothelial cell density, Corneal thickness and Hexagonality of cells were measured in each eye by specular microscopy and were compared between two groups.
Results:
The endothelial cell density in eyes with pseudo exfoliation was 2212.60 ± 312.34 cells/mm2 & in controls 2588.06 ± 286.54cells/mm2. The average cell size of cases was 492.40 ± 72.12 mm2 and of controls was 426.44 ± 73.40 mm2 (p<0.05).
Hexagonality of corneal cells in the cases varied from 11 % to 90 % with a mean of
48.35 %. The controls had a mean of 62.02 % (p<0.05). There was a statistical difference in the cell density, cell size and hexagonality of the two groups.
Conclusion:
Our study showed that in Pseudo exfoliation syndrome, endothelial cell density and the percentage of hexagonal cells are reduced. However, average cell size was increased.
Therefore, ophthalmologists must be careful in conducting cataract surgery, use of high viscosity viscoelastics.
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References
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