TYPE B Natriuretic Peptide (NT-PROBNP), a Multipurpose Biomarker? A Possible Use In Pediatric Pneumology

Giovanni Cacciaguerra (1) , Monica Palermo (2) , Salvatore Michele Carnazzo (3) , Giusi Maria. Caltabiano (4) , Desireè Balconara (5) , Maria Papale (6) , Giuseppe Fabio Parisi (7) , Salvatore Leonardi (8)
(1) , Italy
(2) Clinica di Radiologia, EOC, Istituto Imaging della svizzera italiana, Lugano, Switzerland , Italy
(3) Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, 95125 Catania, Italy. , Italy
(4) Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, 95125 Catania, Italy. , Italy
(5) Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, 95125 Catania, Italy. , Italy
(6) Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy. , Italy
(7) Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy. , Italy
(8) Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy. , Italy
https://doi.org/10.52845/CMRO/2022/5-9-5

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Vol. 5 No. 09 (2022)
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Abstract

B-type natriuretic peptide is a neurhormone isolated in ventricular cardiomyocytes and influences the balance of sodium and water by inducing natriuresis, diuresis and vasodilation, counteracting the renin-angiotensin-aldosterone system.  The N-terminal pro-B natriuretic peptide (NT-proBNP), formed by 76 amino acids, has no bioactivity, the bioptive peptide is composed of 32 amino acids and derives from the cleavage of a precursor molecule. Type B natriuretic peptide is secreted mainly by the ventricles in response to the increase of left or right ventricular pressure and volume loads. Historically, B-type natriuretic peptide levels are related to one's severity and prognosis congestive and left ventricular heart failure. However, some studies have shown that NT-proBNP levels can also be elevated in diseases not purely cardiac such as acute infections, such as sepsis and other diseases in children. The association between serum levels of NTproBNP now measured in series and severity is the goal of numerous studies of the disease in children with pulmonary arterial hypertension (PAH). PAH is characterized by a progressive increase in pulmonary vascular resistance in the system pulmonary vascular precapillary, ultimately leading to right ventricular failure and death. Recent than publications, and one of the main ones we refer to for this communication, confirm that NT-proBNP has predictive value not only at diagnosis but also during the entire course of the disease.


The evolution of the serum levels of NT-proBNP over time reflects the pregression and predicts the negative outcome of the patient; therefore, standardized serial monitoring can support clinical decision making on the timing of escalation of therapy and on the list for lung (heart) transplantation. (1) We do not allow cardiologists to use this important non-invasive serum biomarker, we take advantage of a new ally in the daily fight against pediatric lung diseases.


 

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Authors

Giovanni Cacciaguerra
gio.cacciaguerra@gmail.com (Primary Contact)
Monica Palermo
Clinica di Radiologia, EOC, Istituto Imaging della svizzera italiana, Lugano, Switzerland
Salvatore Michele Carnazzo
Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, 95125 Catania, Italy.
Giusi Maria. Caltabiano
Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, 95125 Catania, Italy.
Desireè Balconara
Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Unit of Rare Diseases of the Nervous System in Childhood, University of Catania, 95125 Catania, Italy.
Maria Papale
Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Giuseppe Fabio Parisi
Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Salvatore Leonardi
Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Cacciaguerra , G., Palermo, M. ., Carnazzo, S. M. ., Caltabiano, G. M., Balconara, D. ., Papale, M. ., Parisi, G. F. ., & Leonardi, S. . (2022). TYPE B Natriuretic Peptide (NT-PROBNP), a Multipurpose Biomarker? A Possible Use In Pediatric Pneumology . Journal of Current Medical Research and Opinion, 5(09), 1396–1398. https://doi.org/10.52845/CMRO/2022/5-9-5
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