Nanotechnology for Cancer Chemotherapy: Design of a Drug Delivery System, Characterization and Fabrication of Drug Delivery Carriers
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Nanotechnology, Drug Delivery System, Design, Cancer Chemotherapy
Abstract
Non-selective anti-cancer drugs given systemically remain a problem because of their action on all cells in the body. These cytoxic drugs affect both the healthy and malignant cells of the body which cause side effects that are sometimes lethal. In the latest whims, novelties of cytotoxic drugs have provided mixtures having worst physiochemical characteristics, thus calling for other options than the invasive one for delivering the package to the diseased tissue. Problems with normal chemotherapy administration, drug transport, and formulation have been resolved by the use of nanoparticles in the delivery of chemotherapeutic medicines to cancer tissue or the tissue microenvironment. Nanoparticles, which are colloidal structures smaller than or equal to one micrometre, can penetrate the tumor's vascular walls, enter the tumor stroma, attach to the surface receptors on tumor cells, and control the release of anti-cancer medications locally. This implies that obtaining a desired copy of the target depends critically on the colloidal carrier's surface design. A long-circulating, targeted, and biocompatible drug delivery particle device. Several drug delivery systems which have proven their therapeutic potential are considered, and the need for the engineering of colloidal carriers which can be used in anticancer therapy is explained. Cancer is an ailment that has become rampant and elaborated in the lives of most individuals globally, and is always a potential cause of poor quality life. However, there is always a deficiency of sufficient cancer treatments, though effective formulations of strategies which helps to: Prevent these, reduce the fatalities, reduce the endurances of chronic pains, or enhance the over quality. Among the key stages towards effective cancer management some of the most significant are distinguishing cancer cells and the administration of drug which has very limited effects on surrounding tissues. Due to non-specificity and inability to elicit response from tumors by the conventional cancer diagnostic and therapeutic modalities; other methods like nanotechnology are employed for better diagnosis and to minimize the disease progression. Several immunotherapeutic agents derived from the nanotechnology aspect of treatment of several types of cancer using nanotherapeutic approaches with selective destruction of cancer cells with minimal invasion on the normal cells. Carbon nanotubes that is one of the main nanomaterials used in developing anticancer drugs have shown good pharmacokinetics and pharmacodynamics in the diagnosis and management of cancer. This review provides an overview of nanomaterial classes that are considered as the basic forms, being used extensively for the detection and treatment of cancer diseases.
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