Innovative Journal Journal of Medical Biomedical and Applied Sciences 2589-8779 11 05 Application of Alkaline Solution by a Nebulizer, Rotahaler and Inhaler in Prevention of Spread of Covid-19 1 Dr. Indranil Chakraborty Pathologist of Kalna Sub-Divisional and Super-Speciality Hospital, West Bengal, India Journal Article https://doi.org/10.15520/jcmro.v3i05.289 Abstract: The emergence of SARS-CoV-2 is the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-COV) and the Middle East respiratory syndrome coronavirus (MERS-COV). Even after taking thousands of human lives, there is no effective curative treatment till date. This virus infects human body by means of aerosol, droplets and contact. Mucous membrane mainly respiratory epithelium is the point of entry in case of SARS-COV2. Then it fuses with the pneumocytes and macrophages of respiratory epithelium by a complex protein-protein interaction. And this initial vital process of fusion needs acidic micro-environment. Here I propose a novel therapeutic approach that can prevent the entry of the virus into host cell and thus will curb down the infection rate and its severity significantly. Moderate alkaline solution of sodium bicarbonate will be used by a nebulizer, rotahaler or inhaler to the respiratory tract to make the airway surface fluid alkaline from acidic and this will hinder the entry of virus to host cells. van Doremalen, Neeltje, Bushmaker, Trenton, Morris, Dylan H., Holbrook, Myndi G., Gamble, Amandine, Williamson, Brandi N., Tamin, Azaibi, Harcourt, Jennifer L., Thornburg, Natalie J., Gerber, Susan I., Lloyd-Smith, James O., de Wit, Emmie, Munster, Vincent J., Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1, New England Journal of Medicine, 2020, 382, 16, 1564, 1567, 0028-4793, 1533-4406, 10.1056/nejmc2004973, Massachusetts Medical Society, https://dx.doi.org/10.1056/nejmc2004973 Lin, L, Lu, L, Cao, W, Li, T, Hypothesis for potential pathogenesis of SARS-CoV-2 infection--a review of immune changes in patients with viral pneumonia. Emerging Microbes & Infections, 2020, 1, 4 Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan, SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell, 2020, 181, 2, 271, 280.e8, 0092-8674, 10.1016/j.cell.2020.02.052, Elsevier BV, https://dx.doi.org/10.1016/j.cell.2020.02.052 Belouzard, Sandrine, Millet, Jean K., Licitra, Beth N., Whittaker, Gary R., Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein, Viruses, 2012, 4, 6, 1011, 1033, 1999-4915, 10.3390/v4061011, MDPI AG, https://dx.doi.org/10.3390/v4061011 Fröhlich, Eleonore, Mercuri, Annalisa, Wu, Shengqian, Salar-Behzadi, Sharareh, Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds, Frontiers in Pharmacology, 2016, 7, 181, 181, 1663-9812, 10.3389/fphar.2016.00181, Frontiers Media SA, https://dx.doi.org/10.3389/fphar.2016.00181 Fischer, Horst, Widdicombe, Jonathan H., Mechanisms of Acid and Base Secretion by the Airway Epithelium, Journal of Membrane Biology, 2006, 211, 139, 150, 0022-2631, 1432-1424, Springer Science and Business Media LLC, 10.1007/s00232-006-0861-0, https://dx.doi.org/10.1007/s00232-006-0861-0 Zou, L, Ruan, F, Huang, M, Liang, L, Huang, H, Hong, Z, Yu, J, Kang, M, Song, Y, Xia, J, Guo, Q, SARS-CoV-2 viral load in upper respiratory specimens of infected patients, New England Journal of Medicine, 2020, 382, 12, 1177, 1186 Davis, M. D., Walsh, B. K., Dwyer, S. T., Combs, C., Vehse, N., Paget-Brown, A., Pajewski, T., Hunt, J. F., Safety of an Alkalinizing Buffer Designed for Inhaled Medications in Humans, Respiratory Care, 2013, 58, 1226, 1232, 0020-1324, 1943-3654, Daedalus Enterprises, 10.4187/respcare.01753, https://dx.doi.org/10.4187/respcare.01753 Rothan, Hussin A., Byrareddy, Siddappa N., The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak, Journal of Autoimmunity, 2020, 109, 102433, 102433, 0896-8411, 10.1016/j.jaut.2020.102433, Elsevier BV, https://dx.doi.org/10.1016/j.jaut.2020.102433 Eschenbacher, William L., Gross, Kenneth B., Muench, Stephen P., Chan, Tai L., , Inhalation of an Alkaline Aerosol by Subjects with Mild Asthma Does Not Result in Bronchoconstriction, American Review of Respiratory Disease, 1991, 143, 341, 345, 0003-0805, American Thoracic Society, 10.1164/ajrccm/143.2.341, https://dx.doi.org/10.1164/ajrccm/143.2.341